Comparative Analysis -- The UK MRC funds the Comparative Genomics Group at the School of Biological & Chemical Sciences, QMUL. The group, headed by Greg Elgar, is involved in a number of projects geared towards understanding sequence data generated by the human genome project. Fugu rubripes (the Japanese puffer fish) is particularly suited to this kind of analysis because whilst its 400Mb genome is eight times smaller than human's, it has a similar repertoire of genes. These genome characteristics along with the large evolutionary distance between bony fish and mammals make Fugu a useful tool for studying gene evolution (see Elgar et al 1999 and Aparicio et al 2002). Please use the links in the navigation bars at the bottom of this webpage to access areas of the website.
Fugu rubripes Research in the group is focused on the annotation of functional non-coding sequences in the human genome. We have recently identified a number of non-coding sequences that are highly conserved throughout vertebrates, and which appear to be associated with developmental regulation. We are taking both computational and functional approaches in order to learn more about what how these sequences act, and what they do. FOR MORE... See also Woolfe et al 2005.

Fugu Resources Available from Geneservice
Fugu Physical Map
Fugu-Human Synteny Viewer
Draft sequence of the Fugu Genome assembly release 4